Mission
Our mission is to develop diagnostic and therapeutic technologies based on plasmonic and optical properties of colloidal nanoparticles. Besides supporting researchers, this platform offers a wide spectrum of services (e.g., fabrication of plasmonic nanoparticle, design of optical devices, and provision of different ultrafast lasers for theranostic applications). These newly developed technologies, supported by TransMedTech, respond to the growing needs in healthcare for a fast and accurate diagnosis facilitating personalized therapy.
Expertise
Sergiy Patskovsky, PhD: contact
Expert in the fabrication of multifunctional biocompatible nanomaterials and bioconjugation techniques.
- Development of multifunctional nanomaterials and surfaces (i.e., plasmonics, biodegradable polymers, and porous nanostructures) for theranostics.
- Surface functionalization and characterization of nanomaterials and analysis of their biological interactions.
- Development of diagnostic platforms based on electro-optical biosensors designing the next generation of portable, personalized and point-of-care biosensing devices aimed at facilitating real-time reliable analysis and diagnostics of cardiovascular diseases, and tumors.
- Multiplexed plasmonic and SERS imaging technologies to generate minimally invasive in-vivo diagnosis and improve current cytopathology diagnostic approaches in vitro. Application of immunoplasmonic biophotonic probe for selective labeling of target cells for consecutive imaging and cytopathology diagnosis.
- Development of site-specific drug and gene delivery systems based on the optical systems employing plasmonic nanoparticle assisted ultrafast laser optoporation, transfection and phototherapy. Development of optically activated porous nanoparticles for a site-specific therapeutic delivery.
- Production of microstructures by femtosecond laser micromachining and fast prototyping of optical and microfluidic systems.
Services MADE AVAILABLE TO CUSTOMERS
Bio-Imaging: Laboratory for the design, synthesis, characterization, and use of novel plasmonic nanoprobes for a precise detection and therapy. Multiplexed plasmonic nanoparticles implemented in a spectral and hyperspectral optical diagnostic system for the detection and diagnosis of cancer cells in vivo and in vitro.
Bio-Sensor: Laboratory of design, experimental realization and commercial prototyping of optical, electro-optical and electro-chemical biosensors. A theoretical design and technological realization of plasmonic nanostructures for ultrasensitive biosensing.
Bio-Laser: Laboratory of high power pulsed and continuous laser for the development of new method of cellular optoporation, gene therapy, transfection in high throughput or single cell precision.
In collaboration with the start-up Vegaphoton (https://vegaphoton.com), we design and build different optical devices (i.e., side-illumination microscopy adaptor, hyperspectral camera, surface plasmon resonance, and plasmonic spectrometer) as well as plasmonic particles.
equipment MADE AVAILABLE TO CUSTOMERS
- Lasers (Femtosecond laser Tsunami (45 fs; 800 nm, 6 mJ/pulse) and Hurricane micromachining system (120 fs, 800 nm, 1 kHz), laser Nd: YAG Millenia with acousto-optic modulation at nanosecond regime, laser Nd:Yag nano BrillantB, Quantel (5 ns, 1064 nm - 1 J/pulse, 532 nm 0.4 J/pulse – 266 nm - 0.1 J/pulse), supercontinuum picosecond laser 400-1600 nm, as well as the equipment for manipulating the pulse widths of the Tsunami (45fs up to ps) at different wavelengths)
- SPR setups (Phase contrast and Phase sensitive SPR)
- Polarimetric nanoplasmonic setup (He-Ne laser, Diode laser in NIR and IR, SLED source)
- Newton Andor spectrometer
- Optical and fluorescence microscopes and side-illumination adaptors
- Hyperspectral imaging systems (high resolution 3D imaging system)
- Plasmonic nanoparticles synthesis and functionalization facilities
- J.A. Woollam ellipsometer (Lamp spectra: 250-1600 nm)
- Solartron Analytical potentiostats
- Cell culture biosafety cabinets, incubators (CO2 water-jacketed incubator) and western-blot set up
lead researcher
Michel Meunier, Full Professor, Department of Engineering Physics, Polytechnique Montréal
Director (interim) of the Department of Engineering Physics, Fellow of CAE (Canadian Academy of Engineering), Fellow of SPIE (International Society for Optics and Photonics), Fellow of OSA (Optical Society of America) and Canada Research Chair (2002-2016).
Access:
TransMedTech members:
Collaborative projects and fee for service requests: user fees at cost (technician time, materials and maintenance). These costs should be included into the budget of each project.
Non-TransMedTech academic users:
Collaborative projects and fee for service requests: user fees at cost (HQP $60/hour and technician time, materials and maintenance.
External users, industries:
We regularly welcome industries to use our laboratories and expertise. For industries, the cost for the use of the laboratories facilities such as the laser is $500/hour, including HQP time. For other smaller equipment, the cost is $100/hour (including HQP time). Reduced fees may be considered if for longer period, an industrial employee is trained to be an independent user of a specific equipment. Consulting fee of the HQP is $60/hour.
