Join us!

The LP2L gives you the possibility to obtain a summer scholarship as well as scholarships for graduate studies to work on groundbreaking projects. We are seeking Masters and PhD graduate students to join our multidisciplinary team developing new biomedical nanotechnologies for theranostics nanomedecine using plasmonic nanostructures and ultrafast lasers. Some researches are performed in strong collaborations with researchers in hospitals.

Research activities

Femtosecond engineering:

Micro/Nano processing of materials, laser pulse shaping, laser-matter interaction simulation. Filamentation in complex waters.

Biomedical nanotechnology:

Nanobiomaterial engineering, gold/silver alloys nanoparticles, silver nanostars, plasmonic fabrication and characterization.

Plasmonic nanobiosensors:

Nanoplasmonic, phase sensitive plasmonic biosensors, SPR microscopy, Raman spectroscopy with plasmonic amplification, gaz sensor, applications to DNA, virus and bacterial detection.


Laser surgery in living cell, cell transfection by laser and plasmonic enhanced transfection, theory and simulation, cancer treatment. Gene therapy for ophtalmology (cornea and retina).


Cancer therapy

One of the main drawbacks of chemotherapy treatment is its lack of specificity for cancer cells. Only 5% of the injected dose is able to kill the tumor cells. The project consists in increasing the specificity between the cancer cells and the chemotherapy.



Encapsulation of the anti-cancer drug in long-lived lipid nanoparticles named liposomes (LNPs) has been shown to reduce these toxic side effects and improve tumor accumulation by utilizing the enhanced vessel retention and permeability (EPR) effect. These same lipid nanoparticles are the basis of the COVID-19 vaccine.


Plasmonic effect of gold nanoparticles

It is also possible to excite gold nanoparticles at a distance using a laser beam to induce a plasmonic resonance effect. With an 800nm femtosecond laser, a single pulse is sufficient to release the drug without compromising cell integrity.

TransMedTech Platform


Our mission is to develop diagnostic and therapeutic technologies based on plasmonic and optical properties of colloidal nanoparticles. Besides supporting researchers, this platform offers a wide spectrum of services (e.g., fabrication of plasmonic nanoparticle, design of optical devices, and provision of different ultrafast lasers for theranostic applications). These newly developed technologies, supported by TransMedTech, respond to the growing needs in healthcare for a fast and accurate diagnosis facilitating personalized therapy.

TMT logo


Vega BioImaging

Our spin-off, Vega BioImaging develops imaging and detection technology based on the plasmonic optical properties of colloidal nanoparticles and designed nanostructures. This technology responds to the growing needs in healthcare for fast and accurate diagnosis and personalized therapies.

To find out more, visit our website:

Logo Vega BioImaging





The NanoEye project gathers two projects for targeted drug delivery in the eye: 


  (c) Leonidas Agiotis
Femtosecond laser filamentation is a complex nonlinear optical phenomenon. It may be described as the propagation of a phenomenologically non-diffracting beam when the pulse duration becomes sufficiently shorter than the characteristic interaction time scales with matter. The induction of such light filaments may lead to several interesting effects (among others, compression of ultrashort pulses, dramatic spectral broadening termed supercontinuum and generation of broadband ultrashort terahertz pulses), which renders it appealing for potential applications.


From nanoparticle to biomarker...
GreenNPs on Hela Cells
 Alloy NPs on HeLa cells - (c) Cécile Darviot
The surface modification of the nanoparticles by attaching specific antibodies transforms the nanoparticles into biomarkers, which will target the cells carrying the antigens that we want to identify. The use of nanoparticles of different colors, functionalized with different antigens, thus opens the way to quantitative multiplexing in cytopathology. We propose to use here four markers, ranging from blue to red, composed of gold-silver alloys or gold only.